This is completely doable with a registry editor, or if your keyboard has a driver (usually its the particular keyboard's driver that was used to do it with) then you can of course make any key function as you'd like.

My Logitech K810 Bluetooth illuminated board allows me to disable keys simply by clicking a check box. I sometimes disable the WINDOWS key and CAPSLOCK for instance. It occasionally was a little pain to undo, but nothing too major. Look into it with just a simple search for yourself and or for him/herself.

-Etherhead