Thanks gytfunke, I have a crude version working from the Mapworks but it needs a lot of refining and doesnt work quite like I want yet, anything you have that you could share would be most helpful!

Here's a concept mod that shows it in action so far, it's a bit rough n' ready but it works, and it shows things off quite nicely so you can see where I'm going with this. Just click where you want to go and voila!

I strongly advise making a character just to test this in case anything goes wrong with the waypoints system. Console to the mapworks and click the World Map (which has replaced the waypoint portal) to see it. Note that by design, this is intended only for the Mapworks as this is a high level area that can teleport to anywhere else. It is possible to implement this anywhere but it needs some tricky scripting (especially to get you to warp back to your town portal if you set it anywhere else in the world).

https://drive.google.com/file/d/0B5w_m-h6MlfvTTdLYm1FWEdWV3M/view?usp=sharing

Would be helpful if you could play with it at different resolutions and post any findings.

EDIT: changed the link as I updated the file after I fixed the image map offsets and I forgot to add a 'close' button, screenie here;-